Exploring Ocular Disorders in Parkinson's Disease: A Comprehensive Review and Future Perspectives

Exp Eye Res. 2024 Dec 24:110225. doi: 10.1016/j.exer.2024.110225. Online ahead of print.

Abstract

Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by predominantly motor symptoms. However, recent research has broadened our understanding of PD by revealing its impact on non-motor functions, including ocular manifestations. This review explored the intricate relationship between PD and ocular health, shedding light on the mechanisms underlying common ocular diseases such as dry eye disease, cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy. It also underscores the importance of recognizing ocular manifestations as potential early markers of PD, as well as their impact on patients' daily activities, necessitating prompt identification and intervention to prevent complications and enhance the overall quality of life. Furthermore, future research should prioritize unraveling the potential association between PD and other prevalent ocular diseases, such as myopia, to formulate effective treatment strategies.

Keywords: Parkinson’s disease; clinical management; ocular diseases; pathophysiological mechanism.

Publication types

  • Review