Three new compounds of Umbelopsis dimorpha VDG10, a dominant endophytic fungus from Vaccinium dunalianum Wight

Zhi-Yu Zhang; Xiao-Man Fu; Yuan-Cao Shu; Xu-Jie Qin; Ying-Jun Zhang; Ping Zhao; Xiao-Qin Yang; Li-Hua Zou; Wei-Hua Wang; Guo-Lei Zhu

doi:10.1016/j.fitote.2024.106358

Three new compounds of Umbelopsis dimorpha VDG10, a dominant endophytic fungus from Vaccinium dunalianum Wight

Fitoterapia. 2024 Dec 24:106358. doi: 10.1016/j.fitote.2024.106358. Online ahead of print.

Authors

Affiliations

¹ Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650233, PR China.
² Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
³ Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650233, PR China; Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, Zhaotong University, Zhaotong 657000, Yunnan, China. Electronic address: 34016@ztu.edu.cn.
⁴ Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650233, PR China. Electronic address: guoleizhu@163.com.

PMID: 39725089
DOI: 10.1016/j.fitote.2024.106358

Abstract

Three novel compounds, including an aromatic amino acid, dimorine A (1), a suncheonoside derivative, dimoroside A (2), and a phenylpropanoid glycoside, dimoroside B (3), together with four known compounds (4-7) were separated from Umbelopsis dimorpha VDG10, the predominant endophytic fungus found in the roots of Vaccinium dunalianum Wight (Ericaceae). Their structures were elucidated by spectroscopic methods, and the ECD spectrum confirmed the absolute configuration of 3. In addition, the antifungal activities of novel compounds against five phytopathogenic fungi were evaluated. The results indicated that compound 3 has a better inhibitory effect on Alternaria brassicicola than the broad-spectrum antifungal agent thiabendazole, and its MICs of 15.63-7.82 μg/mL.

Keywords: Antifungal activity; Aromatic amino acid; Endophytic fungi; Glycosides; Umbelopsis dimorpha; Vaccinium dunalianum.