Targeting the ubiquitin proteasome system in cancer stem cells

Hind Atta; Dina H Kassem; Mohamed M Kamal; Nadia M Hamdy

doi:10.1016/j.tcb.2024.11.011

Targeting the ubiquitin proteasome system in cancer stem cells

Trends Cell Biol. 2024 Dec 24:S0962-8924(24)00253-8. doi: 10.1016/j.tcb.2024.11.011. Online ahead of print.

Authors

Hind Atta¹, Dina H Kassem², Mohamed M Kamal³, Nadia M Hamdy⁴

Affiliations

¹ School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, Cairo, Egypt.
² Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: dina_kassem@pharma.asu.edu.eg.
³ Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; Health Research Center of Excellence, Drug Research and Development Group, The British University in Egypt, Cairo, Egypt.
⁴ Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: nadia_hamdy@pharma.asu.edu.eg.

PMID: 39721924
DOI: 10.1016/j.tcb.2024.11.011

Abstract

Over the past few years there has been an alarming burst of cancer burden worldwide. Cancer stem cells (CSCs) act as hidden devils within tumors, rendering cancer therapy a strenuous goal. Recently, the ubiquitin proteasome system (UPS) was proved to be an essential contributor to the CSC phenotype. This forum article aims to outline new strategies/technologies targeting UPS modulation in CSCs as a potential novel modality for efficient cancer therapy.