Alteration of host gene and protein expression by manipulative parasites

Chen-Hua Li; Robert Poulin

doi:10.1016/j.pt.2024.11.014

Alteration of host gene and protein expression by manipulative parasites

Trends Parasitol. 2024 Dec 24:S1471-4922(24)00362-3. doi: 10.1016/j.pt.2024.11.014. Online ahead of print.

Authors

Chen-Hua Li¹, Robert Poulin²

Affiliations

¹ Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand.
² Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand. Electronic address: robert.poulin@otago.ac.nz.

PMID: 39721905
DOI: 10.1016/j.pt.2024.11.014

Abstract

Host manipulation mechanisms remain poorly understood. We summarize recent studies using -omics approaches (transcriptomics, proteomics) to explore alteration in gene expression in hosts infected by manipulative parasites. To guide future research, we highlight the common pattern of neuromodulation, as well as other diverse combinations of functions targeted across different host manipulation systems.

Keywords: candidate genes; phenotypic manipulation; proteomics; transcriptomics.