New cheaper human papilloma virus mass screening strategy reduces cervical cancer incidence in Changsha city: A clinical trial

Yue-E Zu; Si-Feng Wang; Xing-Xing Peng; Yong-Chun Wen; Xue-Xiang Shen; Xiao-Lan Wang; Wen-Bo Liao; Ding Jia; Ji-Yang Liu; Xiang-Wen Peng

doi:10.5306/wjco.v15.i12.1491

New cheaper human papilloma virus mass screening strategy reduces cervical cancer incidence in Changsha city: A clinical trial

World J Clin Oncol. 2024 Dec 24;15(12):1491-1500. doi: 10.5306/wjco.v15.i12.1491.

Authors

Affiliations

¹ Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care, Hunan Normal University, Changsha 410001, Hunan Province, China.
² Changsha Hospital for Maternal & Child Health Care Affiliated, Hunan Normal University, Changsha 410001, Hunan Province, China.
³ Department of Administrative Office, Hunan Provincial Health Commission, Changsha 410001, Hunan Province, China.
⁴ Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care, Hunan Normal University, Changsha 410001, Hunan Province, China. pxw1237@163.com.

Abstract

Background: Cervical cancer is the second leading cause of death in women worldwide, second only to breast cancer. Around 80% of women have been infected with human papillomavirus (HPV) in their lifetime. Early screening and treatment are effective means of preventing cervical cancer, but due to economic reasons, many parts of the world do not have free screening programs to protect women's health.

Aim: To increase HPV cervical cancer screening in Changsha and reduce the incidence of cervical cancer.

Methods: Cervical cancer screening included gynecological examination, vaginal secretion examination and HPV high-risk typing testing. Cervical cytology examination (ThinPrep cytology test) was performed for individuals who test positive for HPV types other than 16 and 18. Vaginal colposcopy examination was performed for HPV16 and 18 positive individuals, as well as for those who were positive for ThinPrep cytology test. If the results of vaginal colposcopy examination were abnormal, histopathological examination was performed. We conducted a cost-benefit analysis after 4 years.

Results: From 2019 to 2022, 523437 women aged 35-64 years in Changsha city were screened and 73313 were positive, with a 14% positive rate. The detection rate of precancerous lesions of cervical cancer was 0.6% and the detection rate of cervical cancer was 0.037%. Among 311212 patients who underwent two cancers examinations, the incidence rate was reduced by more than half in the second examination. The average screening cost per woman was 120 RMB. The average cost of detecting early cases was 10619 RMB, with an early detection cost coefficient of 0.083.

Conclusion: Our screening strategy was effective and cost-effective, making it valuable for early diagnosis and treatment of cervical cancer. It is worth promoting in economically limited areas.

Keywords: Cervical cancer screening; Cost-effective; Human papillomavirus; New cheaper screening strategy; ThinPrep cytology test.

Publication types

Clinical Trial