The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients

Qianyu Liu; Qihui Ma; Qingfeng Sun; Xuewei Huang

doi:10.3389/fpsyt.2024.1397375

The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients

Front Psychiatry. 2024 Dec 10:15:1397375. doi: 10.3389/fpsyt.2024.1397375. eCollection 2024.

Authors

Qianyu Liu¹, Qihui Ma², Qingfeng Sun³, Xuewei Huang^{1

4}

Affiliations

¹ Psychological Clinic, Guangxi Chest Hospital, Liuzhou, Guangxi, China.
² Medical Department, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
³ Department of Pulmonary Medicine, Guangxi Chest Hospital, Liuzhou, Guangxi, China.
⁴ Department of Psychiatry & Medical Psychology, The First Affiliated Hospital, College of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.

Abstract

Introduction: This study aims to evaluate the effects of group computer magnanimous therapy (GCMT) on magnanimous-enterprising levels and brain metabolic changes in patients with advanced lung cancer.

Methods: In this multicenter, randomized controlled trial, 47 participants diagnosed with advanced stage (III or IV) lung cancer were randomly assigned to either the GCMT group (GCMTG, n = 31) or the control group (CTRLG, n = 16). The GCMTG received routine oncotherapy and care along with eight sessions of GCMT over 2 weeks, while the CTRLG received only oncotherapy and routine care. Psychological and brain metabolic changes were assessed using the Enterprising and Magnanimous Questionnaire (EMQ) and proton magnetic resonance spectroscopy (¹H-MRS).

Results: After 2 weeks, the GCMTG showed significant improvements in the EMQ "total score" and "enterprising" dimensions compared to baseline (p < 0.05), while the CTRLG showed no significant changes. Significant increases in NAA/Cr levels were observed in the right amygdala, and significant decreases in mI/Cr levels were observed in the right cingulate gyrus in the GCMTG. Pearson correlation analysis indicated that changes in Cho/Cr levels in the left amygdala and Glx/Cr levels in the left hippocampus were significantly correlated with improvements in the enterprising dimension.

Conclusions: GCMT significantly enhanced enterprising attitudes and induced beneficial changes in brain metabolites among patients with advanced lung cancer. Further research with larger sample sizes is warranted to confirm these results and explore the long-term effects of GCMT.

Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=129557, identifier ChiCTR2100053015.

Keywords: brain metabolism; group computer magnanimous therapy; lung cancer; magnanimous-enterprising level; psychosomatic effects.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by grants from the Natural Science Foundation of China (NSFC): grant no. 81372488.