The impact of long-term exposure to NO2, O3, and their oxidative potential on adolescents' mental health, and the protective role of school-based greenness

Jiajia Dang; Yaqi Wang; Ning Ma; Shan Cai; Jianhui Guo; Yunfei Liu; Haoyu Zhou; Xinyao Lian; Di Shi; Ziyue Chen; Yihang Zhang; Jiaxin Li; Tianyu Huang; Guangrong Zhu; Jing Li; Jun Ma; Yi Song

doi:10.1016/j.envint.2024.109212

The impact of long-term exposure to NO₂, O₃, and their oxidative potential on adolescents' mental health, and the protective role of school-based greenness

Environ Int. 2024 Dec 18:195:109212. doi: 10.1016/j.envint.2024.109212. Online ahead of print.

Authors

Jiajia Dang¹, Yaqi Wang¹, Ning Ma², Shan Cai¹, Jianhui Guo¹, Yunfei Liu¹, Haoyu Zhou¹, Xinyao Lian¹, Di Shi¹, Ziyue Chen¹, Yihang Zhang¹, Jiaxin Li¹, Tianyu Huang¹, Guangrong Zhu¹, Jing Li³, Jun Ma¹, Yi Song⁴

Affiliations

¹ Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China; National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China.
² Vanke School of Public Health, Tsinghua University, Beijing 100084, China.
³ Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China; National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China. Electronic address: jing.li@hsc.pku.edu.cn.
⁴ Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China; National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China. Electronic address: songyi@bjmu.edu.cn.

PMID: 39719755
DOI: 10.1016/j.envint.2024.109212

Abstract

Recent increases in nitrogen dioxide (NO₂) and ozone (O₃), two highly reactive and oxidative pollutants, have raised concerns about their potential impact on adolescent mental health. This study leveraged data from the Chinese National Survey on Students' Constitution and Health (CNSSCH) in 2019, a nationally representative cross-sectional survey of Chinese adolescents. A total of 149,697 adolescents aged 10-18 years were included in this study. NO₂ and O₃ were sourced from the ChinaHighAirPollutants dataset, and the combined oxidative potential (O_X) was subsequently calculated using the concentrations of NO₂ and O₃. The study quantitively examined the association of NO₂, O₃, and O_X with adolescent mental health using the Dual Factor Model of Mental Health (DFM), which was derived from a questionnaire. According to the DFM, mental health status was divided into four groups: complete mental health, vulnerable, symptomatic but content, and troubled. Greenness around schools, measured by the Normalized Difference Vegetation Index (NDVI), was examined for its potential effect modification on the association between NO₂, O₃, O_X, and mental health. Each IQR (Interquartile Range) increase in O_X was related to adverse mental health outcomes, with ORs of 1.17 (95 % CI: 1.06, 1.29) for being vulnerable, 1.20 (95 % CI: 1.12, 1.28) for being more symptomatic but content, and 1.15 (95 % CI: 1.07, 1.23) for being troubled. Similar findings emerged in relation to O₃ exposure. A positive association was observed between NO₂ exposure and being vulnerable (OR = 1.07; 95 % CI: 1.01, 1.16). Additionally, the impact of exposure to NO₂, O₃, and O_X on mental health outcomes was significantly stronger in the low-level NDVI group compared to the high-level NDVI group (P for interaction < 0.05). The joint effects analysis revealed that adolescents exposed to high levels of air pollutants and low NDVI had the highest odds of adverse mental health outcomes. These results highlight the complex relationship between NO₂, O₃, O_X, and mental health, with particular emphasis on the underexplored role of O_X. Notably, the findings suggest that reducing pollution and increasing greenery could offer significant benefits for improving adolescent mental health.

Keywords: Greenness; Mental health; Nitrogen dioxide; Oxidative potential; Ozone.