Aggregation-induced emission(AIE)for next-generation biosensing and imaging: A review

Keyi Ren; Bangjie Zhang; Jiuchuan Guo; Hanyu Cao; Jie Cheng; Jinhong Guo; Diangeng Li

doi:10.1016/j.bios.2024.117067

Aggregation-induced emission(AIE)for next-generation biosensing and imaging: A review

Biosens Bioelectron. 2024 Dec 14:271:117067. doi: 10.1016/j.bios.2024.117067. Online ahead of print.

Authors

Keyi Ren¹, Bangjie Zhang², Jiuchuan Guo³, Hanyu Cao¹, Jie Cheng⁴, Jinhong Guo⁵, Diangeng Li⁶

Affiliations

¹ School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
² School of Mechanical Science and Engineering, Huazhong University of Science & Technolgy, Wuhan, 430074, China.
³ School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
⁴ School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: chengjie190@sjtu.edu.cn.
⁵ School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Western (Chongqing) Collaborative Innovation Center for Intelligent Diagnostics and Digital Medicine, Chongqing, 401329, China. Electronic address: guojinhong@sjtu.edu.cn.
⁶ Department of Academic Research, Beijing Ditan Hospital, Capital Medical University, National Center for Infectious Diseases, 8th Jingshun East Road, Beijing, 100015, China. Electronic address: lidaingeng@126.com.

PMID: 39718275
DOI: 10.1016/j.bios.2024.117067

Abstract

Luminescence technology is a powerful analytical tool for biomedical research as well as for marker detection. Luminescent materials with aggregation-induced emission (AIE) properties have attracted extensive research interest, and their unique luminescence characteristics, biocompatibility, and sensitivity make them useful for the development of fluorescence-turn-on biosensors with superior sensitivity. While numerous reviews have focused on the design of AIEgens, comprehensive summaries on the strategies for biosensor preparation and application fields remain limited. In this review, we provide a concise introduction to the discovery and mechanism of the AIE phenomenon and summarize the working principles of classic AIE molecules. We discuss luminescence tuning strategies and functionalization methods for AIEgens, along with the design and preparation of AIE-based biosensors. Typical applications of AIE in biosensing and imaging are outlined, and we analyze the current limitations and future research directions of AIE technology in these fields. We hope this review will serve as a valuable reference for researchers in this rapidly developing field. The insights provided may facilitate the rational design of next-generation biosensors based on AIE technology, exhibiting promising avenues of biomedical applications and vast potential for growth.

Keywords: Aggregation-induced emission (AIE); Biomedical application; Biosensing; Imaging.