Background: Oxidative stress and neuroinflammation play critical roles in the pathogenesis of migraine, a neurovascular disease. Cryptoxanthin is a carotenoid known for its potent antioxidant and anti-inflammatory properties. However, the specific association between serum cryptoxanthin levels and migraine remains unclear. This study aims to evaluate the correlation between migraine and serum cryptoxanthin levels.
Methods: For this cross-sectional analysis, information was gathered from individuals ≥20 years who took part in the National Health and Nutrition Examination Survey from 2001 to 2004. Details information was collected on migraines, serum cryptoxanthin levels and various crucial factors. Multivariable logistic regression and restricted cubic spline regression analyses were performed to investigate the relationship between serum cryptoxanthin and the occurrence of migraines.
Results: The study included 8,645 participants, of whom 20.00%(1734/8645) experienced migraine. There was a nonlinear relationship (p < 0.001) between serum cryptoxanthin levels and migraine, which was depicted as an L-shaped curve. The occurrence rate of individuals with serum cryptoxanthin levels below 26.64 nmol/dL experiencing migraine was 0.976 (95% CI: 0.965∼0.987, p<0.001).
Conclusion: In adults among the United States, increased levels of serum cryptoxanthin were associated with decreased risk of migriane with a turning point at around 26.64 nmol/dL in American adults. Further studys are needed to confirm our findings.
Keywords: Migraine; NHANES; cross-sectional study; serum cryptoxanthin.