Tissue engineering presents promising avenues for addressing issues related to tissue defects and regenerative medicine. However, the translational efficacy of tissue engineering in clinical settings remains limited, primarily due to the inadequate survival rates of implanted tissue scaffolds. This is attributed to the grafts' inability to adequately supply oxygen and their dependence on the diffusion of oxygen from surrounding tissues for tissue regeneration. The integration of oxygen-releasing materials in human tissue engineering is anticipated to enhance the hypoxic microenvironment for tissue regeneration. In recent years, a variety of oxygen-producing or oxygen-carrying biomacromolecules, including gelatin, chitosan, and alginate, have been developed, offering innovative strategies for controlled drug release efficacy, regenerative medicine, and biological systems engineering. This review examines applications of these oxygen-releasing biological macromolecules, primarily derived from natural polymeric materials, in diverse facets of human tissue engineering including skin, heart tissue, tumor therapy. We also highlight recent advancements in this field, with an emphasis on current challenges, potential solutions, and future perspectives.
Keywords: Heart tissue; Oxygen-releasing biomacromolecules; Skin; Tissue engineering; Tumor therapy.
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