Resveratrol ameliorates postoperative cognitive dysfunction in aged mice by regulating microglial polarization through CX3CL1/CX3CR1 signaling axis

Jinming Liu; Yong Wang; Hong Sun; Daoyun Lei; Jufeng Liu; Yuanhui Fei; Chunhui Wang; Chao Han

doi:10.1016/j.neulet.2024.138089

Resveratrol ameliorates postoperative cognitive dysfunction in aged mice by regulating microglial polarization through CX3CL1/CX3CR1 signaling axis

Neurosci Lett. 2024 Dec 21:847:138089. doi: 10.1016/j.neulet.2024.138089. Online ahead of print.

Authors

Jinming Liu¹, Yong Wang², Hong Sun¹, Daoyun Lei³, Jufeng Liu¹, Yuanhui Fei¹, Chunhui Wang¹, Chao Han⁴

Affiliations

¹ Department of Anesthesiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
² Department of Anesthesiology, Yixing Hospital of Traditional Chinese Medicine, Yixing, Jiangsu, China.
³ Department of Anesthesiology, Zhongda Hospital Affiliated to Medical College of Southeast University, Nanjing, Jiangsu, China.
⁴ Department of Anesthesiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. Electronic address: staff940@yxph.com.

PMID: 39716583
DOI: 10.1016/j.neulet.2024.138089

Abstract

Postoperative cognitive dysfunction (POCD) is a common cognitive challenge faced by older adults. One of the key contributors to the development of POCD is neuroinflammation induced by microglia. Resveratrol has emerged as a promising candidate for the prevention of cognitive decline. Previous studies have demonstrated its potential in alleviating cognitive deterioration, yielding encouraging results. Nonetheless, the mechanism of resveratrol improving cognitive function remains unclear. Therefore, we assessed the effect of resveratrol in both aged POCD model mice and BV2 cells on CX3CL1/CX3CR1 axis, a critical signaling pathway mediating microglial activity. Both in vitro and in vivo experiments have revealed that pre-administration of resveratrol not only mitigates cognitive deficits but also significantly reduces the levels of inflammatory cytokines. Additionally, it enhanced the expression of SIRT1 and CX3CR1 within the hippocampal region. We also evaluated the impact of resveratrol on CX3CR1 siRNA transfected BV2 cells. Delete of CX3CR1 reversed the preventive role of resveratrol. Our findings implied that resveratrol might inhibit microglial activation and improve cognition by mediating CX3CL1/CX3CR1 signaling.

Keywords: CX3CL1/CX3CR1; Microglia; Postoperative cognitive dysfunction; Resveratrol.