Distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples

Md Kaisar Rahman; Babafela Awosile

doi:10.1016/j.idnow.2024.105019

Distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples

Infect Dis Now. 2024 Dec 21;55(1):105019. doi: 10.1016/j.idnow.2024.105019. Online ahead of print.

Authors

Md Kaisar Rahman¹, Babafela Awosile²

Affiliations

¹ Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, USA. Electronic address: kaisar.rahman@ttu.edu.
² Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, USA. Electronic address: babafela.awosile@ttu.edu.

PMID: 39716556
DOI: 10.1016/j.idnow.2024.105019

Abstract

Background: This study aimed to explore the distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples.

Methods: We analyzed data from 83 countries through the Antimicrobial Testing Leadership and Surveillance program, spanning 2004 to 2021. We calculated the proportion of each β-lactamase gene across nine bacterial species and generated a heatmap for β-lactamase genes with a frequency of ≥ 1 % in at least one species.

Results: A total of 359 β-lactamase genes were identified, with the highest proportion found in Klebsiella spp. (61.84 %, n = 222), followed by Escherichiacoli (47.63 %, n = 171), and Proteus spp. (20.61 %, n = 74). The ESBL gene bla_CTX-M-15 was most prevalent in Klebsiella spp. (62.39 %) and E.coli (53.16 %). The carbapenemase genes bla_NDM-1, bla_OXA-48, and bla_KPC-2 were notably higher in Providencia spp. (59.47 %), Raoultella spp. (45.45 %), and Serratia spp. (25.24 %), respectively.

Conclusion: Further surveillance and research are needed to investigate the diversity of β-lactamase genes across One Health interfaces.

Keywords: Beta-lactamase genes; Distribution; Enterobacteriaceae; blaCTX-M−15; blaNDM-1.