Macrophage metabolic reprogramming: A trigger for cardiac damage in autoimmune diseases

Lin Liu; Minghao Li; Chunyu Zhang; Yi Zhong; Bin Liao; Jian Feng; Li Deng

doi:10.1016/j.autrev.2024.103733

Macrophage metabolic reprogramming: A trigger for cardiac damage in autoimmune diseases

Autoimmun Rev. 2024 Dec 21;24(3):103733. doi: 10.1016/j.autrev.2024.103733. Online ahead of print.

Authors

Lin Liu¹, Minghao Li¹, Chunyu Zhang¹, Yi Zhong¹, Bin Liao², Jian Feng³, Li Deng⁴

Affiliations

¹ Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Stem Cell Immunity and Regeneration Key Laboratory of Luzhou, Luzhou, China.
² Department of Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, China.
³ Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Stem Cell Immunity and Regeneration Key Laboratory of Luzhou, Luzhou, China. Electronic address: jerryfeng@swmu.edu.cn.
⁴ Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Stem Cell Immunity and Regeneration Key Laboratory of Luzhou, Luzhou, China; Department of Rheumatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address: dengli014121@swmu.edu.cn.

PMID: 39716498
DOI: 10.1016/j.autrev.2024.103733

Abstract

Macrophage metabolic reprogramming has a central role in the progression of autoimmune and auto-inflammatory diseases. The heart is a major target organ in many autoimmune conditions and can sustain functional and structural impairments, potentially leading to irreversible cardiac damage. There is mounting clinical evidence pointing to a link between autoimmune disease and cardiac damage. However, this association remains poorly understood, and numerous patients do not receive appropriate preventive measures, which poses serious cardiovascular risks and significantly impacts their quality of life. This review discusses the relationship between macrophage metabolic reprogramming and cardiac damage in patients with autoimmune diseases and the role of adaptive immunity in macrophage reprogramming. It also provides an overview of the immunosuppressive therapies used at present. Exploiting the properties of macrophage reprogramming could lead to development of novel treatments for patients with autoimmune-related cardiac damage.

Keywords: Autoimmune diseases; Cardiac damage; Macrophage metabolic reprogramming.

Publication types

Review