Pathological studies on skeletal muscle atrophy in common fish products from El-Jubail Province, Saudi Arabia

Sci Rep. 2024 Dec 23;14(1):30594. doi: 10.1038/s41598-024-76880-2.

Abstract

In this study, 10 fish species, Jayan flounder (Pseudorhombus javanicus); Oriental sole (Eurgglossa arientalis); Oange-spotted grouper (Epinephelus coioides); Blacktip trevally (Caranx heberi); Towbar seabream (Acanthopagrus bifascia); Smalltooth emperor (Lethrinus microdon); Spangled emperio (Lethrinus nebulous); Sharptooth hammer croaker (Johnius vogleri); Bigeye croaker (Pennahia anea) and Redspine thread bream (Nemipterus nemurus), were examined in El-Jubail province, Saudi Arabia, Arabian Gulf region over three years from 2017 to 2020. The examined fish species showed muscular atrophy in a total percent of 1.1%, but with variable percentages of affections in each species. The highest incidence (2.06%) was oberved in Spangled emperior (Lethrinus nebulous) while the lowest incidence (0.40%) was in Orange spotted grouper (Epinephelus coioides) and Smalltooth emperor (Lethrinus microdon). The affected fishes appeared with sunken eyes, severe emaciation, and prominent loss of skeletal muscle mass. During dissection, the muscular tissue in some examined species was rough while in others, it was edematous and gelatinous, and the internal organs of all fishes were atrophied. For routine histopathological examination, the tissue samples were fixed in 10% buffered neutral formalin. The examined tissue sections of the affected muscles showed variable degrees of histopathological changes depending on the species. Vacuolation of muscle fibers, Zenker's necrosis and myophagia were common in some species, while melanophores aggregation, edema, and hemorrhages were the most commonly observed changes in others. This study focused on the impact of this myodegenerative disease on the marketability of these edible fish species. Further investigation is needed to understand the impact of genetic predisposition, environmental pollution and other etiological agents on the occurrence of this phenomenon in this location.

Keywords: Arabian Gulf; Edible fish; Histopathology; Muscular atrophy.

MeSH terms

  • Animals
  • Fish Diseases / epidemiology
  • Fish Diseases / pathology
  • Fish Products / adverse effects
  • Fishes
  • Muscle, Skeletal* / pathology
  • Muscular Atrophy* / etiology
  • Muscular Atrophy* / pathology
  • Muscular Atrophy* / veterinary
  • Saudi Arabia / epidemiology