Objective: Aim: Our study aimed to investigate the connection between the ABCC8 gene polymorphisms (rs1801261 and rs757110) and T2DM in the Iraqi Middle Euphrates region. Patients with type 2 diabetes were chosen because they were treated with glibenclamide and glimepiride.
Patients and methods: Materials and Methods: The groups of this case-control study are the control group obviously healthy persons included 400 (235 Male/165 Female) and 400 T2DM group (213 Male/ 187 Female). The FSG, HDL-Ch, Total-Ch, LDL-Ch, and Tgs are measured and genotyping of these two SNPs.
Results: Results: Our findings that FSG augmented in CA and AA codominant styles of rs757110. Moreover, there were decreased insulin and BMI significantly (p = 0.002 & 0.026 respectively) in CA and AA codominant patterns of rs757110. Likewise, glucose was high significantly (0.017) and reduced insulin and BMI (p = 0.001 & 0.013 respectively) in dominant pattern (CA+AA) of rs757110. As codominant pattern (of rs757110), AA carriers revealed significant (p = 0.03) risky (OR = 1.83) when adjustment with age, BMI and sex. Additionally, after controlling for gender, age, and dominant pattern, CA + AA carriers had a significant (p = 0.02) risk factor for diabetic disease (OR = 1.45). There was no correlation between rs1801261, and T2DM.
Conclusion: Conclusions: The rs757110 related to less insulin excretion in T2DM of Iraqi Middle Euphrates population who received glimepiride and glibenclamide for diabetes treatment.
Keywords: ABCC8 gene; Polymorphisms; Type 2 diabetes mellitus; sulfonylurea receptors.