Unlocking the Potential of Carrier Mediated Nano-biomedicine in Management of Diabetes Mellitus: A review

Chem Biodivers. 2024 Dec 23:e202402258. doi: 10.1002/cbdv.202402258. Online ahead of print.

Abstract

Diabetes is a medical condition, which belongs to the group of chronic diseases that affects how body processes glucose, the primary source of energy for cells. Glucose comes indirectly from the consumed food and is carried by bloodstream to various cells in body. Insulin, a hormone synthesized by pancreas play a vital role in conversion of glucose to energy. Managing diabetes involves regular monitoring of blood sugar levels, adopting a healthy diet, engaging in regular physical activity, and taking medications or insulin as prescribed by a healthcare provider. Proper management of diabetes may lead to prevention or delay of diabetic complications may further sever other diseases associated impediment. Drug delivery in the management of diabetes is designed to administer insulin or other diabetes medications in a controlled and convenient manner. Recently several natural products have been studied and reported for their potential role in managing diabetes. While they may not replace standard medical treatments, some of these natural products could complement existing therapies and support overall diabetes management. In this review phyto-pharmacological aspect of bioactive in the management of diabetes has been elaborated. Moreover, their fortification within nanocarriers was further taken in discussions with update information on clinical trial study.

Keywords: Drug Delivery Carriers; Nanomedicine; Nanotechnology; bioactive compounds; diabetes.