[Cu(NHC)(OR)] (R = C(CF3)3) complexes for N-H and S-H bond activation and as pre-catalysts in the Chan-Evans-Lam reaction

Tommaso Ruggiero; Kristof Van Hecke; Catherine S J Cazin; Steven P Nolan

doi:10.1039/d4dt03322a

[Cu(NHC)(OR)] (R = C(CF₃)₃) complexes for N-H and S-H bond activation and as pre-catalysts in the Chan-Evans-Lam reaction

Dalton Trans. 2024 Dec 23. doi: 10.1039/d4dt03322a. Online ahead of print.

Authors

Tommaso Ruggiero¹, Kristof Van Hecke¹, Catherine S J Cazin¹, Steven P Nolan¹

Affiliation

¹ Department of Chemistry and Center for Sustainable Chemistry, Ghent University, Krijgslaan 281 (S-3), 9000, Ghent, Belgium. steven.nolan@ugent.be.

PMID: 39714204
DOI: 10.1039/d4dt03322a

Abstract

The synthesis, isolation, and full characterization of a series of NHC-copper perfluoro-alkoxide complexes are reported. Their exceptional stability resides with the steric hindrance of the nonafluoro-tert-butyl alkoxide moiety, which exhibits a strong electron withdrawing effect. These new Cu(I) complexes are synthons that can permit the activation of acidic N-H and S-H bonds. The well-defined [Cu(IPr)(OC(CF₃)₃)] was investigated as a pre-catalyst in the Chan-Evans-Lam reaction.