Case report: A rare case of intragastric metastasis after liver transplantation for liver cancer

Youfeng Xue; Baojie Shi; Jianfa Zhong; Guimei Wang; Jie Wang; Wenbin An; Yunyun Qian; Zhaojie Su; Zhihai Peng; Hao Li

doi:10.3389/fonc.2024.1495517

Case report: A rare case of intragastric metastasis after liver transplantation for liver cancer

Front Oncol. 2024 Dec 6:14:1495517. doi: 10.3389/fonc.2024.1495517. eCollection 2024.

Authors

Youfeng Xue^#¹, Baojie Shi^#², Jianfa Zhong^#², Guimei Wang², Jie Wang², Wenbin An², Yunyun Qian², Zhaojie Su², Zhihai Peng², Hao Li²

Affiliations

¹ Hepatobiliary Surgery Department, Fuqing Hospital, Fuzhou, Fujian, China.
² Organ Transplantation Clinical Medical Center of Xiamen University, Department of Organ Transplantation, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.

^# Contributed equally.

Abstract

A 13-year-old boy was admitted to Xiang'an Hospital of Xiamen University due to HBV-related liver cancer. Intrahepatic metastasis was considered to occur by CT scan. A gastroscope revealed esophagogastric variceal bleeding, and later, the patient underwent a successful liver transplantation. Fourteen months posttransplant, chest CT indicated lung metastasis, and the patient underwent thoracoscopic radical resection of lung cancer. Twenty-one months posttransplant, gastroscopy revealed a gastric fundus tumor growing into the gastric cavity. Proximal gastrectomy was performed, and pathology indicated moderately to poorly differentiated carcinoma without invasion of serosa, suggesting the first study to report HCC metastasis to the stomach lumen without invasion of serosa after LT. Currently, the alpha-fetoprotein (AFP) level of the patient has dropped below normal.

Keywords: hepatocellular carcinoma; intragastric metastasis; liver cancer; liver transplantation; pediatric liver transplantation.

Publication types

Case Reports

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work received financial support from the Natural Science Fund for Distinguished Young Scholars of Fujian Province (2023J01310519).