Development of an amorphous octenyl succinate anhydride starch-based emulsion to improve the stability and bioaccessibility of phloretin

Zheming Zhang; Baoxin Gu; Lingjin Li; Zhengbiao Gu; Li Cheng; Yan Hong

doi:10.1016/j.ijbiomac.2024.138948

Development of an amorphous octenyl succinate anhydride starch-based emulsion to improve the stability and bioaccessibility of phloretin

Int J Biol Macromol. 2024 Dec 18:290:138948. doi: 10.1016/j.ijbiomac.2024.138948. Online ahead of print.

Authors

Zheming Zhang¹, Baoxin Gu², Lingjin Li², Zhengbiao Gu³, Li Cheng³, Yan Hong⁴

Affiliations

¹ School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Jiaxing Institute of Future Food, Jiaxing 314050, Zhejiang Province, People's Republic of China.
² School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China.
³ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China.
⁴ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Jiaxing Institute of Future Food, Jiaxing 314050, Zhejiang Province, People's Republic of China; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China. Electronic address: hongyan@jiangnan.edu.cn.

PMID: 39706445
DOI: 10.1016/j.ijbiomac.2024.138948

Abstract

Phloretin (PHT) is a natural functional compound with antioxidant properties. However, its poor water solubility and high sensitivity to extreme pH environments, oxygen, and high temperatures limit its absorption and stability. Therefore, in this study, amorphous octenyl succinic anhydride starch (AOS) was employed to enhance the stability of PHT-loaded emulsions, and characteristics of these emulsions were evaluated. In total, three AOS samples with varying degrees of amorphous were prepared as emulsifiers. Notably, amorphous starch prepared at 90 °C was found to stabilize the emulsion by forming a superior gel network structure, facilitating the efficient loading of PHT and protecting this compound from degradation in extreme environments. Finally, in vitro digestion and release experiments confirmed the effectiveness of these emulsions in PHT delivery. Compared to the existing β-cyclodextrin-PHT drug delivery system, the prepared emulsion exhibited superior PHT release at the site of intestinal absorption. Therefore, the emulsions established in this study show promise as PHT delivery systems for future applications in the food industry.

Keywords: Emulsion delivery system; Octenyl succinic anhydride starch; Phloretin.