Features of internal absorbed dose microdistribution in biological tissue irradiated by 31SiO2 microparticles compared with dose microdistribution from exposure to 56MnO2 particles

Valeriy Stepanenko; Andrey Kaprin; Sergey Ivanov; Peter Shegay; Viktoria Bogacheva; Sergey Shinkarev; Hitoshi Sato; Noriyuki Kawano; Megu Ohtaki; Nariaki Fujimoto; Satoru Endo; Aya Sakaguchi; Evgenia Ostroumova; Kassym Zhumadilov; Almagul Kushugulova; Masaharu Hoshi

doi:10.1093/jrr/rrae096

Features of internal absorbed dose microdistribution in biological tissue irradiated by 31SiO2 microparticles compared with dose microdistribution from exposure to 56MnO2 particles

J Radiat Res. 2024 Dec 19:rrae096. doi: 10.1093/jrr/rrae096. Online ahead of print.

Authors

Valeriy Stepanenko¹, Andrey Kaprin^{2

3

4}, Sergey Ivanov^{1

3}, Peter Shegay², Viktoria Bogacheva¹, Sergey Shinkarev⁵, Hitoshi Sato⁶, Noriyuki Kawano⁷, Megu Ohtaki⁷, Nariaki Fujimoto⁸, Satoru Endo⁹, Aya Sakaguchi¹⁰, Evgenia Ostroumova¹¹, Kassym Zhumadilov¹², Almagul Kushugulova¹³, Masaharu Hoshi⁷

Affiliations

¹ A. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, Kaluga Region 249036, Russian Federation.
² National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva Str., 4., Obninsk, Kaluga Region 249036, Russian Federation.
³ Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow 117198, Russian Federation.
⁴ P.A. Hertzen Moscow Oncology Research Institute-branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2nd Botkinsky Drive 3, Moscow 125284, Russian Federation.
⁵ State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 46 Zhivopisnaya St., Moscow 123098, Russian Federation.
⁶ Ibaraki Prefectural University of Health Sciences, 4669-2 Ami, Ami-machi, Inashiki-gun, Ibaraki 300-0394, Japan.
⁷ The Center for Peace, Hiroshima University, Higashisenda-machi 1-1-89, Naka-ku, Hiroshima 730-0053, Japan.
⁸ Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
⁹ Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1, Kagamiyama, Higashi, Hiroshima 739-8527, Japan.
¹⁰ Institute of Pure and Applied Sciences, University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
¹¹ Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer/WHO, 25 avenue Tony Garnier, Lyon 69366, France.
¹² International Department of Nuclear Physics, New Materials and Technology, L. N. Gumilyov Eurasian National University, Munaitpasova 13, office 300, Astana, Kazakhstan.
¹³ Nazarbayev University, 53 Kabanbay Batyr Avenue, Nur-Sultan city 010000, Kazakhstan.

PMID: 39699238
DOI: 10.1093/jrr/rrae096

Abstract

Radiobiological studies are ongoing to understand the consequences of internal exposure to neutron-activated radioactive microparticles, which were sprayed over experimental rats and mice. Special attention in these experiments is given to internal irradiation with radioactive microparticles with short-lived neutron-activated radionuclides 31Si (T1/2 = 2.62 h) and 56Mn (T1/2 = 2.58 h), which are among the main dose-forming factors from residual radioactivity activated in soils by neutrons in the first hours after atmospheric nuclear explosions. The presented work is devoted to microdosimetry peculiarities of 31SiO2 and 56MnO2 microparticles. The radiation from 31Si consists of intensive short-range beta particles and gamma rays with very low intensity. It differs from the radiation of 56Mn, which includes intensive beta particles, low energy Auger electrons and very intensive gamma rays. Differences in the energies and intensities of short-range beta particles and penetrating gamma rays emitted by 31SiO2 and 56MnO2 microparticles can lead to differences in the spatial microdistribution of absorbed dose around the corresponding radioactive microparticles embedded in biological tissue. It was found in the presented work that the absorbed doses of beta radiation emitted by 56MnO2 and 31SiO2 microparticles has significant but different spatial gradients with distances in biological tissue that correspond to the typical thickness of epithelial cells of lungs' alveoli and bronchioles. The results obtained are necessary for a better understanding of radiobiological effects of internal exposure by radioactive microparticles with 56Mn and 31Si observed in framework of performed and ongoing radiobiological studies with experimental animals-rats and mice.

Keywords: 31Si; 56Mn; alveoli; bronchioles; internal irradiation; lungs; radiation dose microdistribution; radioactive microparticles.