Convenient lanthanum-mediated synthesis of bulky tert-alkyl amines from nitriles

Chem Commun (Camb). 2025 Jan 14;61(6):1172-1175. doi: 10.1039/d4cc05831c.

Abstract

Tert-alkyl amines can be conveniently prepared in one step from nitriles by a double addition of ethyl or propyl Grignard reagent mediated by a commercially available lanthanum chloride-lithium chloride complex solution. The reaction operates on a variety of benzonitriles, with several heterocyclic nitriles and an alkyl nitrile also being suitable substrates.