Objectives: To analyze the regularity of acupoint selection and compatibility of acupuncture and moxibustion for Parkinson's disease (PD) using complex network analysis technology, so as to provide the basis and treatment strategies for clinical acupuncture and moxibustion treatment of PD.
Methods: Relevant literature published in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, and Web of Science from the inception to December of 2023 was retrieved. The literature was screened based on inclusion and exclusion criteria to establish a prescription database for acupuncture treatment of PD. Excel was used to analyze the frequency of use of acupoints, meridian normalization and specific acupoints. The IBM SPSS Modeler18.0 was used for modeling and association rule analysis, while the Gephi0.10.1 was utilized for complex network analysis.
Results: A total of 326 valid articles were included, from which 496 valid acupuncture prescriptions were extracted, involving 251 acupoints with a total usage frequency of 3, 968 times. The top 5 most frequently used acupoints were Baihui (GV20, 225 times), Taichong (LR3, 215 times), Fengchi (GB20, 202 times), Hegu (LI4, 192 times), and Sanyinjiao (SP6, 134 times). The second-order and third-order association rules between the acupoints indicated that the combinations of LI4-LR3 and GB20-LR3-LI4 had the highest support. After analyzing the complex network topology, 27 core acupoints for the treatment of PD were identified. Commonly used meridians are Governer Vessel, Gallbladder Meridian of Foot Shaoyang , Stomach Meridian of Foot Yangming. He-sea acupoints and yuan-source acupoints are the majority in the specific acupoints. The community analysis of the acupoints revealed 3 groups：the head acupoints group of the Governor Vessel, the acupoints group for nourishing the liver and kidney, and the acupoints group for expelling pathogens and purging excessiveness.
Conclusions: Acupuncture and moxibustion treatment for PD often emphasizes the use of he-sea acupoints and yuan-source acupoints, and focus on combination of upper and lower acupoints, as well as the selection of acupoints within the same meridian. The treatment is based on zang-fu and meridian differentiation, with selection of the Governor Vessel to calm the mind and compatibility with acupoints to regulate the liver and tonify the kidney for the root causes, while utilizing limb acupoints to dispel wind, resolve phlegm, eliminate dampness, and purge heat for the symptoms.
目的: 利用复杂网络技术分析针灸治疗帕金森病（PD）的选穴配伍规律，为临床针灸治疗PD提供依据及治疗思路。方法: 检索中国知网、万方、维普及PubMed、Web of Science 5个数据库从建库至2023年12月针灸治疗PD的临床研究文献，依据纳入和排除标准筛选文献，建立针灸治疗PD的处方数据库。使用Excel统计腧穴使用频次归经、特定穴。用IBM SPSS Modeler18.0软件建模，进行关联规则分析，利用Gephi0.10.1软件进行复杂网络分析。结果: 共检索到3 893篇文献，最终纳入326篇有效文献，提取出有效针灸处方496条，共涉及251个腧穴，总使用频次3 968次，使用频次前5的腧穴分别是百会（225次）、太冲（215次）、风池（202次）、合谷（192次）、三阴交（134次）。常用经脉为督脉、足少阳胆经、足阳明胃经，特定穴中以合穴、原穴居多。腧穴间二阶、三阶，四阶关联规则显示，合谷-太冲、风池-太冲-合谷支持度最高；复杂网络拓扑结构分析后明确了27个针灸治疗PD的核心节点腧穴；腧穴社团分析得到督脉头部腧穴群、滋补肝肾治本腧穴群及祛邪泻实治标腧穴群3个社团。结论: 针灸治疗PD重用合穴及原穴，以上下配穴及同经选穴为主，治疗基于脏腑经络辨证，选督脉以调神志，配伍滋肝肾、补气血的腧穴以调肝补肾治其本，肢体腧穴以祛风、化痰、祛湿、泄热治其标。.
Keywords: Acupoint compatibility; Acupuncture and moxibustion therapy; Complex network analysis; Literature study; Parkinson’s disease.