Tracking healing effect of human Wharton's jelly stem cells labeled with superparamagnetic iron oxide nanoparticles seeded onto poly vinyl alcohol/chitosan/carbon nanotubes in burn wounds by MRI, and Prussian Blue staining

Seyedeh-Sara Hashemi; Zeinab Niknam; Seyed Mojtaba Zebarjad; Davood Mehrabani; Reza Jalli; Mahdi Saeedi-Moghadam; Rezvan Behroozi; Shahrokh Zare; Iman Jamhiri; Amin Derakhshanfar; Javad Moayedi; Mehra Nazempour; Aghdass Rasouli-Nia; Feridoun Karimi-Busheri; Hossein Ali Khonakdar

doi:10.1088/1748-605X/ad9fc6

Tracking healing effect of human Wharton's jelly stem cells labeled with superparamagnetic iron oxide nanoparticles seeded onto poly vinyl alcohol/chitosan/carbon nanotubes in burn wounds by MRI, and Prussian Blue staining

Biomed Mater. 2024 Dec 16. doi: 10.1088/1748-605X/ad9fc6. Online ahead of print.

Authors

Affiliations

¹ Shiraz University of Medical Sciences, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, 71348-14336, Iran (the Islamic Republic of).
² Department of Materials Science and Engineering, Shiraz University, Department of Materials Science and Engineering, Shiraz University, Shiraz, Iran, Shiraz, 71946-84636, Iran (the Islamic Republic of).
³ Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Tehran, 71348-14336, Iran (the Islamic Republic of).
⁴ Department of Biomedical, Islamic Azad University, Department of Biomedical and Tissue Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran, Tehran, 19585-466, Iran (the Islamic Republic of).
⁵ Department of Oncology, Shiraz University of Medical Sciences, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, Fars, 71348-14336, Iran (the Islamic Republic of).
⁶ Department of Polymer Processing, Iran Polymer and Petrochemical Institute, Department of Polymer Processing, Iran Polymer and Petrochemical Institute, P.O. Box 14965-115, Tehran, Iran, Tehran, 1497713115, Iran (the Islamic Republic of).

PMID: 39681069
DOI: 10.1088/1748-605X/ad9fc6

Abstract

Regenerative medicine by applying tissue engineering and cell transplantation has provided a new door in wound healing. This study tracked healing effect of human Wharton's jelly stem cells (WJSCs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs) seeded onto poly vinyl alcohol/chitosan/carbon nanotubes (PVA/CS/CNT) in burn wounds by magnetic resonance imaging (MRI) and Prussian Blue staining.&#xD.

Keywords: Poly vinyl alcohol/chitosan/carbon nanotubes; Wharton’s jelly stem cells; burn; healing; rat; wound.