Pineal Gland Activity in Advanced-Stage Pediatric Neuroblastoma Patients on 68Ga-DOTATATE PET/CT

Emine Goknur Isik; Dilara Denizmen; Dilşad Fırat Arslan; Duygu Has Simsek; Zeynep Gözde Özkan

doi:10.1097/RLU.0000000000005626

Pineal Gland Activity in Advanced-Stage Pediatric Neuroblastoma Patients on 68Ga-DOTATATE PET/CT

Clin Nucl Med. 2024 Dec 13. doi: 10.1097/RLU.0000000000005626. Online ahead of print.

Authors

Emine Goknur Isik¹, Dilara Denizmen, Dilşad Fırat Arslan, Duygu Has Simsek, Zeynep Gözde Özkan

Affiliation

¹ From the Department of Nuclear Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

PMID: 39668492
DOI: 10.1097/RLU.0000000000005626

Abstract

Neuroblastoma is the most common malignancy in infants and the most common extracranial solid tumor accounting for approximately 6% of pediatric cancer. Although surgical intervention serves as the primary treatment for early-stage disease, advanced-stage cases necessitate a variety of oncologic therapeutic approaches, including 131I-MIBG and peptide receptor radionuclide therapy. Herein we report incidental pineal gland activity, represented in 68Ga-DOTATATE PET/CT (SSTR-PET) in 3 pediatric patients diagnosed with stage 4 neuroblastoma, related to the physiological distribution of radiopharmaceuticals.