Effects of non-invasive brain stimulation over the supplementary motor area on motor function in Parkinson's disease: A systematic review and meta-analysis

Yawen Chen; Hanhong Jiang; Yixin Wei; Saiqing Ye; Jiaxin Jiang; Margaret Mak; Marco Y C Pang; Qiang Gao; Meizhen Huang

doi:10.1016/j.brs.2024.12.005

Effects of non-invasive brain stimulation over the supplementary motor area on motor function in Parkinson's disease: A systematic review and meta-analysis

Brain Stimul. 2024 Dec 11;18(1):1-14. doi: 10.1016/j.brs.2024.12.005. Online ahead of print.

Authors

Yawen Chen¹, Hanhong Jiang², Yixin Wei², Saiqing Ye¹, Jiaxin Jiang³, Margaret Mak³, Marco Y C Pang³, Qiang Gao⁴, Meizhen Huang⁵

Affiliations

¹ Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China.
² Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, China.
³ Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China.
⁴ Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: gaoqiang_hxkf@163.com.
⁵ Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China. Electronic address: mei-zhen.huang@polyu.edu.hk.

PMID: 39667490
DOI: 10.1016/j.brs.2024.12.005

Abstract

Background: Motor dysfunction profoundly affects individuals with Parkinson's disease (PD). Non-invasive brain stimulation (NIBS) targeting the supplementary motor area (SMA), a critical region for movement-related processing, offers a promising approach to enhance motor function for PD.

Objective: This systematic review and meta-analysis aims to evaluate the efficacy of NIBS over the SMA (SMA-NIBS) in alleviating motor symptoms in PD.

Methods: We conducted literature searches in MEDLINE, EMBASE, Physiotherapy Evidence Database, Web of Science, the Chinese National Knowledge Infrastructure, and Scopus. The meta-analysis utilized an inverse variance method and a random-effects model. Subgroup analyses were performed based on stimulation types (e.g., TMS and tDCS), stimulation protocols (e.g., facilitatory and inhibitory stimulation), and medication status during stimulation.

Results: Twenty randomized control trials involving 442 individuals with PD were included. Compared to sham stimulation, SMA-NIBS significantly improved motor function as measured by the motor section of Unified Parkinson's Disease Rating Scale (UPDRS-III) (mean differences [MD]: -3.45, 95 % confidence interval [CI]: -5.65 to -1.26). Subgroup analysis revealed that only TMS (MD: -3.62, 95%CI: -6.15 to -1.08), not tDCS (MD: -2.47, 95 % CI: -5.03 to 0.08), has significant effect on motor function. Both facilitatory (MD: -2.59, 95 % CI: -3.37 to -1.82) and inhibitory stimulation (MD: -4.98, 95 % CI: -9.29 to -0.66) significantly improved the UPDRS-III score. Effectiveness was observed only during ON medication. Statistically significant effects of SMA-NIBS were reported on Freezing of Gait Questionnaire, not timed up and go test and walking speed.

Conclusion: SMA-NIBS is a promising approach to enhance motor function in PD.

Keywords: Motor function; Non-invasive brain stimulation; Parkinson's disease; Supplementary motor area; Transcranial direct current stimulation; Transcranial magnetic stimulation.

Publication types

Review