Comparison of anticoagulant combinations used in granulocyte apheresis

Bera Omer Ugurlu; Tulay Karaagac Akyol; Olgu Erkin Çınar; Osman Ozcebe

doi:10.1016/j.transci.2024.104044

Comparison of anticoagulant combinations used in granulocyte apheresis

Transfus Apher Sci. 2024 Dec 7;64(1):104044. doi: 10.1016/j.transci.2024.104044. Online ahead of print.

Authors

Bera Omer Ugurlu¹, Tulay Karaagac Akyol², Olgu Erkin Çınar³, Osman Ozcebe⁴

Affiliations

¹ Hacettepe University Medical Faculty, Department of Internal Medicine Division of Hematology, Ankara, Turkey. Electronic address: ugurlubera@gmail.com.tr.
² Hacettepe University Medical Faculty Hospitals Blood Center and Apheresis Unit, Ankara, Turkey. Electronic address: drtulaykaraagac@yahoo.com.tr.
³ Hacettepe University Medical Faculty, Department of Internal Medicine Division of Hematology, Ankara, Turkey. Electronic address: drerkincinar@gmail.com.tr.
⁴ Hacettepe University Medical Faculty, Department of Internal Medicine Division of Hematology, Ankara, Turkey; Hacettepe University Medical Faculty Hospitals Blood Center and Apheresis Unit, Ankara, Turkey. Electronic address: oiozcebe@hacettepe.edu.tr.

PMID: 39662126
DOI: 10.1016/j.transci.2024.104044

Abstract

Our study retrospectively examines the number of granulocytes in the products of donors who donated granulocytes between January 2016 and September 2020 at the Hacettepe University Faculty of Medicine Blood Bank. The effects of acid-citrate-dextrose (ACD), trisodium citrate + hydroxyethyl starch (TCC + HES) and ACD + HES combinations used in the apheresis procedure on the granulocyte count of apheresis products were examined. As a result of study, it was seen that the type of anticoagulant combination used during apheresis significantly affected the number of granulocytes collected.

Keywords: Acid-citrate-dextrose; Apheresis; Granulocyte; Hydroxyethyl starch; Trisodium citrate.