High-titer antibodies to interferon-gamma (IFN-γ) are strongly correlated with infections caused by intracellular pathogens, particularly non-tuberculous mycobacteria and Talaromyces marneffei (TM). However, cases of concurrent infections with TM and Mycobacterium tuberculosis (MTB) in non-immunosuppressed patients are extremely rare. We presented a clinical case of a patient with anti-IFN-γ autoantibodies who developed an MTB infection complicated by Talaromyces marneffei, which subsequently led to secondary hemophagocytic syndrome. This report aimed to raise clinicians' awareness of this rare association to minimize the risk of misdiagnosis and overdiagnosis.
高滴度抗γ干扰素（IFN-γ）自身抗体与细胞内病原体感染密切相关，尤其是非结核分枝杆菌和马尔尼菲篮状菌（TM），但有关非免疫抑制宿主同时发生TM和结核分枝杆菌（MTB）感染的报告极少。本文报道1例抗IFN-γ自身抗体阳性的结核分枝杆菌感染合并马尔尼菲篮状菌病继发噬血细胞综合征患者的临床诊疗经过，以期提高临床医生对该病的认识，避免误诊、漏诊。.