According to international comparative data on age-adjusted death rates, male mortality caused by laryngeal cancer in Uruguay is ranked second in the world. This fact has prompted the authors to study time trends and to perform cohort analysis of all deaths due to larynx cancer during the 1958 to 1981 period. Localization as well was investigated by means of incident cases taken from Registry of the University Hospital (1960-1981). Trend analyses have shown an increase in age-adjusted death rates among men. This was largely due to the older age of patients. Cohort analysis showed a decline in mortality among younger patients. As far as anatomic location is concerned, a marked predominance of supraglottic cancer was observed. This was particularly high among those belonging to the low-income group.