Long-Term Refractive and Topographical Changes in Keratoconic Eyes after Accelerated Corneal Crosslinking

Cesk Slov Oftalmol. 2024;80(Ahead of print):1-6. doi: 10.31348/2024/37.

Abstract

Aim: To evaluate the long-term impact of accelerated corneal cross-linking (A-CXL) on selected refractive and topographical parameters in eyes with progressive keratoconus.

Methods: 77 eyes with keratoconus in 54 patients treated with A-CXL (10 min "epi-off" protocol) were included in the analysis. Preoperative and postoperative (1, 3 and 5 years after A-CXL) values of the studied parameters were compared.

Results: In the cohort, there was an improvement in best corrected central visual acuity (BCCVA) 1 year (p = 0.004) and 3 years (p.

Keywords: progressive keratoconus; accelerated corneal cross-linking; refractive and topographical parameters.

MeSH terms

  • Adolescent
  • Adult
  • Collagen / metabolism
  • Corneal Topography*
  • Cross-Linking Reagents*
  • Female
  • Humans
  • Keratoconus* / diagnosis
  • Keratoconus* / drug therapy
  • Keratoconus* / metabolism
  • Keratoconus* / physiopathology
  • Male
  • Photochemotherapy
  • Photosensitizing Agents
  • Refraction, Ocular
  • Riboflavin / therapeutic use
  • Visual Acuity*
  • Young Adult

Substances

  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Riboflavin
  • Collagen