Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel

Daniela Crousillat; Amy Sarma; Malissa Wood; Sahar Naderi; Katherine Leon; C Michael Gibson; Aaron Aday; Anna Grodzinsky; Kathy Izard; Jason C Kovacic; Mark E Lindsay; Dermot Phelan; Patricia F Rodriguez-Lozano; Nandita S Scott; Markus Scherer; Aditya Sharma; Ranya Sweis; Jennifer A Sumner; Esther S H Kim

doi:10.1016/j.jacadv.2024.101385

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel

JACC Adv. 2024 Nov 20;3(12):101385. doi: 10.1016/j.jacadv.2024.101385. eCollection 2024 Dec.

Authors

Daniela Crousillat¹, Amy Sarma², Malissa Wood³, Sahar Naderi⁴, Katherine Leon⁵, C Michael Gibson⁶, Aaron Aday⁷, Anna Grodzinsky⁸, Kathy Izard⁵, Jason C Kovacic^{9

10

11}, Mark E Lindsay¹², Dermot Phelan¹³, Patricia F Rodriguez-Lozano¹⁴, Nandita S Scott¹⁵, Markus Scherer¹⁶, Aditya Sharma¹⁷, Ranya Sweis¹⁸, Jennifer A Sumner¹⁹, Esther S H Kim²⁰

Affiliations

¹ Division of Cardiovascular Sciences, Department of Medicine and Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa General Hospital Heart and Vascular Institute, Tampa, Florida, USA.
² Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
³ Division- Heart Institute, Lee Health Heart Institute, Fort Myers, Florida, USA.
⁴ Division of Cardiology, Kaiser Permanente Northern California, San Francisco, California, USA.
⁵ SCAD Alliance, Alexandria, Virginia, USA.
⁶ PERFUSE Study Group, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee, USA.
⁸ Saint Luke's Mid America Heart Institute/University of Missouri-Kansas City, Kansas City, Missouri, USA.
⁹ Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
¹⁰ Vascular Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
¹¹ St. Vincent's Clinical School, University of NSW, Sydney, New South Wales, Australia.
¹² Cardiovascular Genetics Program, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹³ Gragg Center for Cardiovascular Performance, Sanger Heart & Vascular Institute, Atrium Health, Charlotte, North Carolina, USA.
¹⁴ Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.
¹⁵ Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁶ Sanger Heart and Vascular Institute, Atrium Health, Charlotte, North Carolina, USA.
¹⁷ Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, USA.
¹⁸ Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹⁹ Department of Psychology, University of California, Los Angeles, California, USA.
²⁰ Sanger Heart & Vascular Institute, Atrium Health, Charlotte, North Carolina, USA.

Abstract

Despite marked advancements in the recognition and diagnosis of spontaneous coronary artery dissection (SCAD) over the past decade, knowledge of the basic pathophysiologic mechanisms of disease, contributing factors, and treatment continue to be poorly understood. We describe significant research gaps in our knowledge of SCAD and introduce strategies including the role of patient advocacy, independent registries, and creation of diverse centers of excellence to bridge the gap in clinical care, research, and outcomes. Lastly, we introduce an innovative patient-centered clinical care and research framework established through the SCAD Alliance and International Spontaneous Coronary Artery Dissection registry as a model for advancing knowledge of SCAD.

Keywords: SCAD; health inequity; sex differences.

Publication types

Review