Acne skin care aims to reduce the stratum corneum layer, normalization of sebum secretion, and mitigation of purulent lesions. Antibiotics, such as macrolides, clindamycin, and tetracyclines, are often used in acne treatment. In clinical practice, the resistance of antibiotics has become an increasing issue. Symptoms of acne may vary, so it is crucial to understand the skin’s needs in order to find the cause of acne and to adjust proper skin care, treatment, and diet. This review summarizes treatment methods and novel approaches in skin care to discover the best combination for more favorable curability results. J Drugs Dermatol. 2024;23(12):e181 doi:10.36849/JDD.7757R1e.