A Case Report: PSMA PET/CT in Retroperitoneal Hemangioma

Clin Nucl Med. 2025 Jan 1;50(1):e43-e46. doi: 10.1097/RLU.0000000000005552.

Abstract

Prostate-specific membrane antigen (PSMA) PET/CT scan has significantly improved the detection and staging of prostate cancer. We report a rare case of a 72-year-old man with a history of Gleason score 7 (3 + 4) prostate adenocarcinoma, status post radical prostatectomy, referred for restaging PSMA PET/CT scan due to rising PSA (0.12 μg/L). The scan revealed a PSMA-avid lesion in the retroperitoneum, later confirmed via further investigations and histopathological analysis to be a retroperitoneal hemangioma. This case emphasizes the challenges in interpreting PSMA PET/CT scan in prostate cancer and highlights the significance of thorough consideration in forming a comprehensive differential diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Surface / metabolism
  • Glutamate Carboxypeptidase II / metabolism
  • Hemangioma* / diagnostic imaging
  • Humans
  • Male
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms / diagnostic imaging
  • Prostatic Neoplasms / pathology
  • Retroperitoneal Neoplasms / diagnostic imaging
  • Tomography, X-Ray Computed

Substances

  • Glutamate Carboxypeptidase II
  • FOLH1 protein, human
  • Antigens, Surface