Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer

S-H Lee; J Menis; T M Kim; H R Kim; C Zhou; S A Kurniawati; K Prabhash; H Hayashi; D D-W Lee; M S Imasa; Y L Teh; J C-H Yang; T Reungwetwattana; V Sriuranpong; C-E Wu; Y Ang; M Sabando; M Thiagarajan; H Mizugaki; V Noronha; M Yulianti; L Zhang; E Smyth; T Yoshino; J O Park; G Pentheroudakis; S Park; S Peters; J B Ahn; S Popat

doi:10.1016/j.esmoop.2024.103996

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer

ESMO Open. 2024 Dec;9(12):103996. doi: 10.1016/j.esmoop.2024.103996. Epub 2024 Nov 29.

Authors

S-H Lee¹, J Menis², T M Kim³, H R Kim⁴, C Zhou⁵, S A Kurniawati⁶, K Prabhash⁷, H Hayashi⁸, D D-W Lee⁹, M S Imasa¹⁰, Y L Teh¹¹, J C-H Yang¹², T Reungwetwattana¹³, V Sriuranpong¹⁴, C-E Wu¹⁵, Y Ang¹⁶, M Sabando¹⁷, M Thiagarajan¹⁸, H Mizugaki¹⁹, V Noronha⁷, M Yulianti²⁰, L Zhang²¹, E Smyth²², T Yoshino²³, J O Park²⁴, G Pentheroudakis²⁵, S Park²⁴, S Peters²⁶, J B Ahn⁴, S Popat²⁷

Affiliations

¹ Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: shlee119@skku.edu.
² Medical Oncology Department, University and Hospital Trust of Verona, Verona, Italy.
³ Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
⁴ Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
⁵ Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
⁶ Department of Internal Medicine, Division of Hematology and Medical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia.
⁷ Department of Medical Oncology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India.
⁸ Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan.
⁹ Department of Clinical Oncology, University of Malaya, Kuala Lumpur, Malaysia.
¹⁰ Department of Thoracic Oncology, Lung Center of the Philippines, Quezon City, Philippines.
¹¹ Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
¹² Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.
¹³ Division of Medical Oncology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
¹⁴ Division of Medical Oncology, Faculty of Medicine, Chulalongkorn University and the King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
¹⁵ Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
¹⁶ Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
¹⁷ Internal Medicine Department, Bicol Regional Hospital and Medical Center, Legazpi City, Albay, Philippines.
¹⁸ Department of Radiotherapy and Oncology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
¹⁹ Department of Respiratory Medicine, NHO Hokkaido Cancer Center, Sapporo, Japan.
²⁰ Division of Respirology and Critical Care, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
²¹ State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
²² Department of Oncology, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
²³ Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
²⁴ Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
²⁵ ESMO, Lugano, Switzerland.
²⁶ Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
²⁷ Royal Marsden NHS Trust, London, UK.

Abstract

The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer (mNSCLC), published in January 2023, was modified according to previously established standard methodology, to produce the Pan-Asian adapted (PAGA) ESMO consensus guidelines for the management of Asian patients with oncogene-addicted mNSCLC. The adapted guidelines presented in this manuscript represent the consensus opinions reached by a panel of Asian experts in the treatment of patients with oncogene-addicted mNSCLC representing the oncological societies of China (CSCO), Indonesia (ISHMO), India (ISMPO), Japan (JSMO), Korea (KSMO), Malaysia (MOS), the Philippines (PSMO), Singapore (SSO), Taiwan (TOS) and Thailand (TSCO), co-ordinated by ESMO and the Korean Society for Medical Oncology (KSMO). The voting was based on scientific evidence and was independent of the current treatment practices, drug access restrictions and reimbursement decisions in the different regions of Asia. The latter are discussed separately in the manuscript. The aim is to provide guidance for the optimisation and harmonisation of the management of patients with oncogene-addicted mNSCLC across the different regions of Asia, drawing on the evidence provided by both Western and Asian trials, while respecting the differences in screening practices, molecular profiling and age and stage at presentation. Attention is drawn to the disparity in the drug approvals and reimbursement strategies between the different regions of Asia.

Keywords: ESMO; Pan-Asian; guidelines; non-small cell lung cancer; treatment.

Publication types

Practice Guideline

MeSH terms

Asia / epidemiology
Carcinoma, Non-Small-Cell Lung* / diagnosis
Carcinoma, Non-Small-Cell Lung* / genetics
Carcinoma, Non-Small-Cell Lung* / pathology
Carcinoma, Non-Small-Cell Lung* / therapy
Humans
Lung Neoplasms* / diagnosis
Lung Neoplasms* / genetics
Lung Neoplasms* / pathology
Lung Neoplasms* / therapy
Medical Oncology / standards
Oncogenes
Practice Guidelines as Topic