Adult severe community-acquired pneumonia with bloodstream infection caused by ψUSA 300: A case report

Shinichi Morimoto; Mituhiro Kamada; Yuka Motomura; Nobuhiro Kashige; Motoyasu Miyazaki; Yoshihiko Nakamura; Tohru Takata

doi:10.1016/j.diagmicrobio.2024.116630

Adult severe community-acquired pneumonia with bloodstream infection caused by ψUSA 300: A case report

Diagn Microbiol Infect Dis. 2024 Nov 26;111(3):116630. doi: 10.1016/j.diagmicrobio.2024.116630. Online ahead of print.

Authors

Shinichi Morimoto¹, Mituhiro Kamada², Yuka Motomura³, Nobuhiro Kashige⁴, Motoyasu Miyazaki⁵, Yoshihiko Nakamura⁶, Tohru Takata⁷

Affiliations

¹ Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address: otomirom7960@adm.fukuoka-u.ac.jp.
² Department of Pharmacy, Fukuoka University Hospital, Fukuoka 814-0180, Japan. Electronic address: mkamada@fukuoka-u.ac.jp.
³ Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address: motomura@fihes.pref.fukuoka.jp.
⁴ Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address: kashige@fukuoka-u.ac.jp.
⁵ Department of Pharmacy, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan. Electronic address: motoyasu@fukuoka-u.ac.jp.
⁶ Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address: nakamura58@adm.fukuoka-u.ac.jp.
⁷ Department of Oncology, Hematology and Infectious Disease, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address: takattol@cis.fukuoka-u.ac.jp.

PMID: 39615197
DOI: 10.1016/j.diagmicrobio.2024.116630

Abstract

We report the first case of fatal community-acquired pneumonia with concomitant bloodstream infection caused by the ψUSA300 strain of methicillin-resistant Staphylococcus aureus (MRSA). The isolate was positive for Panton-Valentine leukocidin (PVL) gene, with a unique 12-base pair deletion in the ccrB2 gene, differentiating it from the canonical USA300 strain. Despite aggressive therapeutic interventions, the patient developed multiple complications, including septic shock, which ultimately proved fatal. Genetic sequencing confirmed the presence of the ψUSA300 strain.

Keywords: Antimicrobial treatment; Community-acquired methicillin-resistant Staphylococcus aureus; Extracorporeal membrane oxygenation; Panton–Valentine leucocidin gene; ψUSA300 strain.

Publication types

Case Reports