Host metabolic inflammation fueled by bacterial DNA

Ke Wang; Karina Cunha E Rocha; Houji Qin; Zixuan Zeng; Wei Ying

doi:10.1016/j.tem.2024.11.003

Host metabolic inflammation fueled by bacterial DNA

Trends Endocrinol Metab. 2024 Nov 27:S1043-2760(24)00294-7. doi: 10.1016/j.tem.2024.11.003. Online ahead of print.

Authors

Ke Wang¹, Karina Cunha E Rocha¹, Houji Qin², Zixuan Zeng², Wei Ying³

Affiliations

¹ Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
² School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
³ Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: weying@health.ucsd.edu.

PMID: 39609222
DOI: 10.1016/j.tem.2024.11.003

Abstract

Metabolic diseases, characterized by chronic low-grade inflammation, exhibit a compromised gut barrier allowing the translocation of bacteria-derived products to bloodstream and distant metabolic organs. Bacterial DNA can be detected in metabolic tissues during the onset of these diseases, highlighting its role in the development of metabolic diseases. Extracellular vesicles (EVs) are involved in the delivery of bacterial DNA to the local tissues, and its sensing by the host triggers local and system inflammation. Understanding bacterial DNA translocation and its induced inflammation is crucial in deciphering metabolic disease pathways. Here, we delve into the mechanisms dictating the interaction between host physiology and bacterial DNA, focusing on its origin and delivery, host immune responses against it, and its roles in metabolic disorders.

Keywords: bacterial DNA; complement immunity; extracellular vesicles; immune response; metabolic diseases; tissue inflammation.

Publication types

Review