m6A and beyond: RNA modifications shaping angiogenesis

Yu Luan; Renbing Jia; Peiwei Chai; Xianqun Fan

doi:10.1016/j.molmed.2024.11.001

m⁶A and beyond: RNA modifications shaping angiogenesis

Trends Mol Med. 2024 Nov 27:S1471-4914(24)00302-2. doi: 10.1016/j.molmed.2024.11.001. Online ahead of print.

Authors

Yu Luan¹, Renbing Jia², Peiwei Chai³, Xianqun Fan⁴

Affiliations

¹ Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
² Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address: renbingjia@sjtu.edu.cn.
³ Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address: chaipeiwei123@sjtu.edu.cn.
⁴ Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address: fanxq@sjtu.edu.cn.

PMID: 39609142
DOI: 10.1016/j.molmed.2024.11.001

Abstract

RNA modifications are crucial post-transcriptional processes that significantly influence gene expression, RNA stability, nuclear transport, and translational capacity. Angiogenesis, the formation of new blood vessels, is a physiological process that is dysregulated in many pathological conditions, including ocular diseases, immune disorders, and cancer. In this review, we compile the current understanding of the intricate relationship between various RNA modifications and angiogenic mechanisms, spotlighting emerging evidence that underscore their pivotal regulatory roles in both physiological and pathological angiogenesis. Furthermore, we delve into recent advances in innovative therapeutic approaches that target RNA modifications to modulate angiogenesis, offering insights into their potential as novel treatment modalities.

Keywords: RNA modifications; angiogenesis; biomarkers; epitranscriptomics; therapeutics.

Publication types

Review