Objective:To explore the relevant anatomical factors in the pathogenesis of chronic dacryocystitis based on CT radiomics. Methods:A retrospective analysis was conducted on the general data and sinus CT materials of 85 patients with chronic dacryocystitis（case group） admitted to our department from December 2020 to December 2023, and 85 individuals undergoing physical examination（control group） during the same period. The differences in anatomical parameters between the two groups were compared to study the morphological characteristics of the nasolacrimal duct in patients with chronic dacryocystitis. Univariate and multivariate logistic regression analyses were used to explore the relevant anatomical factors in the pathogenesis of chronic dacryocystitis. Results:There were statistically significant differences（P<0.05） in the proportion of combined nasal septal deviation, the distance between the anterior and posterior ridges of the lacrimal fossa, the angle between the long axis of the nasolacrimal duct and the projection on the midsagittal plane, the maximum transverse diameter of the bony nasolacrimal duct, the maximum cross-sectional area of the bony nasolacrimal duct, and the thickness of the frontal process of the maxilla between the two groups. There were no statistically significant differences（P>0.05） in whether there was a combined high-position nasal septal deviation, whether there was a combined non-high-position nasal septal deviation, and whether there was a combined pneumatized middle turbinate. Multivariate analysis showed that nasal septal deviation, the distance between the anterior and posterior ridges of the lacrimal fossa, the angle between the long axis of the nasolacrimal duct and the projection on the midsagittal plane, and the maximum cross-sectional area of the bony nasolacrimal duct are independent anatomical factors affecting the pathogenesis of chronic dacryocystitis. Conclusion:Nasal septal deviation, a large distance between the anterior and posterior ridges of the lacrimal fossa, a large angle between the long axis of the nasolacrimal duct and the projection on the midsagittal plane, and a small maximum transverse diameter of the bony nasolacrimal duct are important anatomical bases for the pathogenesis of chronic dacryocystitis, providing a basis for an in-depth understanding of the disease occurrence.
目的：以CT组学为基础探究慢性泪囊炎发病的相关解剖学因素。 方法：回顾性分析2020年12月—2023年12月我科收治的85例慢性泪囊炎患者（病例组）和同期85例体检者（对照组）的一般资料和鼻窦CT资料，比较2组解剖学参数的差异，研究慢性泪囊炎患者鼻泪道形态特征。通过单因素和多因素logistic回归分析，探究慢性泪囊炎发病的相关解剖学因素。 结果：2组合并鼻中隔偏曲的比例、泪囊窝前后嵴间距离、鼻泪管长轴与正中矢状切面投影夹角、骨性鼻泪管的最大横径、骨性鼻泪管最大横截面积和上颌骨额突厚度之间差异有统计学意义（P<0.05）。2组是否合并高位鼻中隔偏曲、是否合并非高位鼻中隔偏曲、是否合并泡状中鼻甲差异均无统计学意义（P>0.05）。多因素分析显示，泪囊窝前后嵴间距离、鼻泪管长轴与正中矢状切面投影夹角和骨性鼻泪管的最大横截面积是影响慢性泪囊炎发病的独立解剖学因素。 结论：泪囊窝前后嵴间距离大、鼻泪管长轴与正中矢状切面投影夹角大和骨性鼻泪管最大横径小是慢性泪囊炎发病的重要解剖学基础，为深入认识疾病发生提供依据。.
Keywords: anatomical factors; chronic dacryocystitis; radiomics.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.