Recent studies have detected microplastics (MPs) in reproductive organs and found that they exert toxic effects on the reproductive system. However, the exact mechanism of action remains unclear. This study evaluates changes in MP levels in patients with cervical cancer as the disease progresses and uses untargeted metabolomics to assess the impact of MP exposure on the metabolomic profiles of cervical invasive cancer tissues. A total of 12 MP types were identified in 101 MP particles, with an average abundance of 2.24 ± 1.61 MP particles/g. Of these, polyethylene (PE, 26.73 %) and polypropylene (PP, 19.80 %) were the most frequently detected. Also, some MPs were observed to have sizes smaller than 20 µm. Notably, MP exposure levels increase as cervical cancer progresses (p < 0.05). Metabolomics analysis revealed that, among the 33 biologically significant metabolites screened, D-Mannose and cis,cis-muconic acid showed the most significant differences. Additionally, the aminosugar and nucleotide sugar metabolism pathways were the most significantly enriched in this experiment, potentially acting as pathways through which MPs may contribute to the pathogenesis of cervical cancer. The metabolites and pathways identified in this study may offer new insights and opportunities for disease research in patients with cervical cancer.
Keywords: Cervical cancer; Cervical invasive cancer; D-Mannose; Metabolomics; Microplastics.
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