Alcaligenes faecalis is a Gram-negative, rod-shaped bacterium that is common in the environment and has been reported to have various bioactive metabolites of industrial potential applications, including antifungal, antibacterial, antimycobacterial, antiparasitic, anticancer, antioxidant activities. In this review, we highlighted and discussed the respective metabolites, pointing out their chemical diversities, purification, current challenges, and future directions. A. faecalis has an industrial role in biodegradation, biosurfactants, and different enzyme production. In this review, the up-to-date various Response Surface Methodology methods (RSM) that can be employed for statistical optimization of the bioactive secondary metabolites have been discussed and highlighted, pointing out the optimal use of each method, current challenges, and future directions.
Keywords: Alcaligenes faecalis; antibacterial; antifungal; biocontrol activity; eco-friendly; industrial; optimization; purification; response surface methodology; secondary metabolites.
This study aimed to discuss and highlight all the biologically active metabolites produced by various members of Alcaligenes faecalis. In the literature, it has been reported that this species produces a wide variety of biologically active metabolites for potential industrial applications, including those having antibacterial, antifungal, antimycobacterial, antiparasitic, anticancer, and antioxidant activities. In this review, we point out the chemical diversity and future perspectives of the respective metabolites and different methods that can be employed to optimize their production and make these metabolites of potential industrial use by the producer strains.