The effect of expiratory flow limitation on supine persistent hyperinflation in COPD: a prospective observational study

Meera Srinivasan; Hannah Pollard; David G Chapman; Katrina Tonga; Kieran Patel; Kaj Blokland; David Touma; Cindy Thamrin; Troy Cross; Kim Prisk; Gregory G King

doi:10.1183/23120541.00255-2024

The effect of expiratory flow limitation on supine persistent hyperinflation in COPD: a prospective observational study

ERJ Open Res. 2024 Nov 25;10(6):00255-2024. doi: 10.1183/23120541.00255-2024. eCollection 2024 Nov.

Authors

Meera Srinivasan^{1

2

3

4}, Hannah Pollard¹, David G Chapman^{1

2

5}, Katrina Tonga^{1

2

3}, Kieran Patel^{1

2}, Kaj Blokland^{1

2}, David Touma^{1

2}, Cindy Thamrin^{2

3}, Troy Cross^{2

3}, Kim Prisk^{2

6}, Gregory G King^{1

2

3}

Affiliations

¹ The Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia.
² Airway Physiology and Imaging Group, The Woolcock Institute of Medical Research, Macquarie University, Sydney, NSW, Australia.
³ Faculty of Medicine and Health, Sydney University, Sydney, NSW, Australia.
⁴ Department of Respiratory Medicine, The Canberra Hospital, Garran, ACT, Australia.
⁵ School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
⁶ Department of Medicine, University of California, San Diego, CA, USA.

Abstract

Introduction: COPD is characterised by airflow obstruction, expiratory airway collapse and closure causing expiratory flow limitation (EFL) and hyperinflation. Supine posture may worsen ventilatory function in COPD, which may cause hyperinflation to persist and contribute to symptoms of orthopnoea and sleep disturbance. Our aim was to determine the impact of supine posture on hyperinflation, dynamic elastance and EFL in COPD and healthy subjects. We hypothesised that changes in hyperinflation in supine posture are influenced by EFL and gas trapping in COPD.

Methods: Clinically stable COPD patients (compatible symptoms, smoking >10 pack-years, obstructed spirometry) and healthy controls underwent oscillometry in the seated and supine positions. Hyperinflation was measured by inspiratory capacity (IC) and the ratio of IC to total lung capacity (IC/TLC) while seated and supine EFL was measured as the difference in mean inspiratory and mean expiratory oscillatory reactance at 5 Hz (X _rs5). Relationships between IC, IC/TLC and X _rs5, were examined by Spearman correlation.

Results: 42 COPD patients demonstrated no change in IC/TLC from seated (0.31 L) to supine (0.32 L) position (p=0.079) compared to significant increases seen in 14 control subjects (0.37 L seated versus 0.44 L supine; p<0.001). In COPD, worse dynamic elastance (X _rs5 r_s 0.499; p=0.001) and EFL (ΔX _rs5 r_s -0.413; p=0.007), along with increased age and lower body-mass-index were predictors of supine hyperinflation.

Conclusion: Supine persistent hyperinflation occurs in COPD and is associated with increased dynamic elastance and EFL, likely the result of increased airway closure due to gravitational redistribution of lung mass.