The importance of cognitive correlates of plasma amyloid-β 42/40

Andrea M Weinstein; Marissa A Gogniat; Meryl A Butters

doi:10.1177/13872877241301804

The importance of cognitive correlates of plasma amyloid-β 42/40

J Alzheimers Dis. 2024 Nov 25:13872877241301804. doi: 10.1177/13872877241301804. Online ahead of print.

Authors

Andrea M Weinstein^{1

2}, Marissa A Gogniat³, Meryl A Butters^{1

2}

Affiliations

¹ School of Medicine, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
² Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
³ School of Medicine, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.

PMID: 39584368
DOI: 10.1177/13872877241301804

Abstract

This commentary focuses on the clinical utility of plasma amyloid-β (Aβ) 42/40 to detect semantic intrusion errors in amnestic mild cognitive impairment, as investigated Curiel Cid et al. in a recent issue of the Journal of Alzheimer's Disease. This commentary highlights the importance of testing the sensitivity of plasma Aβ_42/40 to clinical symptoms in the quest to develop a comprehensive definition of AD that incorporates both biological precursors and clinical consequences.

Keywords: Alzheimer's disease; biomarkers; cognition; memory; mild cognitive impairment.