Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

F Smits; Kaz Groen; Mark-David Levin; Claudia Stege; Roel J W van Kampen; Ellen van der Spek; Yavuz M Bilgin; Noortje Thielen; Inger S Nijhof; Inge Ludwig; Esther G M de Waal; Yorick Sandberg; Alain Kentos; Gert-Jan Timmers; Josien C Regelink; Matthijs Westerman; Koen de Heer; Marie-Christiane Mb Vekemans; Nazik Durdu-Rayman; Nicole C H P de Graauw; Maarten R Seefat; Niels W C J van de Donk; Paula F Ypma; Kazem Nasserinejad; Sonja Zweegman

doi:10.1182/blood.2024025868

Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

Blood. 2024 Nov 22:blood.2024025868. doi: 10.1182/blood.2024025868. Online ahead of print.

Authors

F Smits¹, Kaz Groen¹, Mark-David Levin², Claudia Stege³, Roel J W van Kampen⁴, Ellen van der Spek⁵, Yavuz M Bilgin⁶, Noortje Thielen⁷, Inger S Nijhof⁸, Inge Ludwig⁹, Esther G M de Waal¹⁰, Yorick Sandberg¹¹, Alain Kentos¹², Gert-Jan Timmers¹³, Josien C Regelink¹⁴, Matthijs Westerman¹⁵, Koen de Heer¹⁶, Marie-Christiane Mb Vekemans¹⁷, Nazik Durdu-Rayman¹⁸, Nicole C H P de Graauw¹⁹, Maarten R Seefat¹, Niels W C J van de Donk²⁰, Paula F Ypma²¹, Kazem Nasserinejad²², Sonja Zweegman²³

Affiliations

¹ Amsterdam UMC, Amsterdam, Netherlands.
² Department of Internal Medicine, Albert Schweitzer hospital, Dordrecht, the Netherlands., Dordrecht, Netherlands.
³ Erasmus Medical Center, Rotterdam, Netherlands.
⁴ Zuyerland Medical Center, Sittard-Geleen, Netherlands.
⁵ Rijnstate, Doorn, Netherlands.
⁶ ADRZ, Goes, Netherlands.
⁷ Diakonessenhuis, Utrecht, Netherlands.
⁸ St Antonius Ziekenhuis, Nieuwegein, Netherlands.
⁹ Bernhoven Hospital, Uden, Netherlands.
¹⁰ Medical Center Leeuwarden, Leeuwarden, Netherlands.
¹¹ Maasstad Hospital, Rotterdam, Netherlands.
¹² Centre Hospitalier Jolimont, Haine-Saint-Paul, Belgium.
¹³ Amstelland Hospital, Amstelveen, Netherlands.
¹⁴ Meander Medical Center, Amersfoort, Netherlands.
¹⁵ Northwest Clinics, Alkmaar, Netherlands.
¹⁶ Flevoziekenhuis, Almere, Netherlands.
¹⁷ UCL Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹⁸ Franciscus Hospital, location Vlietland, Schiedam, Netherlands.
¹⁹ Bravis Hospital, Roosendaal, Netherlands.
²⁰ Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
²¹ Haga Hospital, The Hague, Netherlands.
²² ErasmusMC University, Rotterdam, Netherlands.
²³ Amsterdam UMC. Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands.

PMID: 39576961
DOI: 10.1182/blood.2024025868

Abstract

The level of frailty, according to the IMWG frailty index, is highly dynamic during anti-myeloma treatment. Dynamic frailty assessment improved the prediction of survival and early mortality as compared to the prognostic value of static frailty level at baseline. HOVON 143: NTR6297 HOVON 123: NTR4244.