Inspired by an ancient Chinese Medicine prescription: the modern significance and potential of Yiyi Fuzi Baijiang San in treating diseases

Yuli Zhang; Lu Zhang; Ni Chai; ZhiQiang Wan; Hua Sui

doi:10.3389/fphar.2024.1465387

Inspired by an ancient Chinese Medicine prescription: the modern significance and potential of Yiyi Fuzi Baijiang San in treating diseases

Front Pharmacol. 2024 Nov 7:15:1465387. doi: 10.3389/fphar.2024.1465387. eCollection 2024.

Authors

Yuli Zhang^#^{1

2}, Lu Zhang^#³, Ni Chai⁴, ZhiQiang Wan^{5

6}, Hua Sui²

Affiliations

¹ Department of Traditional Chinese Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Medical Experiment Center, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
⁴ Oncology Department, Yueyang Hospital of Integrated of Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁵ Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Center for Research and Graduate Studies, University of Cyberjaya, Selangor, Malaysia.

^# Contributed equally.

Abstract

Classic Formulas (Jing fang) are considered the essence and authority of Traditional Chinese Medicine (TCM) due to their long history and proven efficacy. These formulas play a pivotal role in all kinds of different disease prevention and therapeutic strategies. Yiyi Fuzi Baijiang San (YYFZBJS), one of the Classic Formulas, was originally developed for the treatment of chronic intestinal abscess. With the accumulation of clinical experience and the exploration of modern pharmacological research in recent years, YYFZBJS has been extensively employed to address a broad spectrum of conditions such as colorectal cancer. Although numerous studies have explored the clinical efficacy and underlying mechanisms of YYFZBJS, no comprehensive review summarizing these findings exists to date. This study aims to systematically review and critically assess the current clinical and mechanistic research on YYFZBJS, with the objective of providing valuable insights and guidance for TCM research in the future.

Keywords: Yiyi Fuzi Baijiang San; active ingredients; clinical application; mechanism; traditional Chinese medicine.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was funded by “Jiaotong University Star” Program (No. YG2022QN082), the National Natural Science Foundation of China (No. 82204887), the Science Foundation for Shanghai Committee of Science Project (No. 23S21901200), Special Disease Construction Project of Jiading District Health System (No. ZB202406), Special Project of Traditional Chinese Medicine Scientific Research of Henan Province (No. 2024ZY2145), Project of Scientific and technological breakthroughs in Henan Province (No.242102310493), and Henan Province Science and Technology Research and Development Plan Joint Fund Project (No.242301420116).