Multiomic interrogation of an endomembrane disrupting antimalarial

Abstract

Challenges in adapting natural products as antimalarials include their cryptic mechanism of action (and by extension resistance), as well as their complex and expensive synthesis without an abundant natural source. Recently, Chahine et al. presented plausible means to address these challenges in the case of the kalihinol family of isocyanoterpenes.

Keywords: Plasmodium; apicoplast; endoplasmic reticulum; kalihinol; malaria.