Abstract
A series of novel derivatives of Poliacetylene Glycosides (PAGs) were synthesized, and their antiproliferative and antiviral properties were evaluated. Starting from D-(+)-glucose pentaacetate as a precursor, a commercially available and low-cost starting material, three different strategies were attempted to synthesize the new PAGs, and the desired compounds were obtained in high overall yields after only three steps. The synthesized PAGs exhibited antitumoral activity in concentrations ranging from 68-878 μM and antiviral activities in concentrations ranging from 71-794 μM. Some preliminary structure-activity relationships are also discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / chemical synthesis
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / pharmacology
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Antiviral Agents* / chemical synthesis
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Antiviral Agents* / chemistry
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Antiviral Agents* / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Glycosides* / chemical synthesis
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Glycosides* / chemistry
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Glycosides* / pharmacology
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Polyynes* / chemical synthesis
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Polyynes* / chemistry
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Polyynes* / pharmacology
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Structure-Activity Relationship
Substances
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Glycosides
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Antiviral Agents
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Antineoplastic Agents
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Polyynes