Bionic cell wall models: Utilizing TEMPO-oxidized cellulose nanofibers for fucoxanthin delivery systems

Fang Tian; Shuyi Xu; Miaoyu Gan; Baihui Chen; Qian Luan; Luyun Cai

doi:10.1016/j.carbpol.2024.122850

Bionic cell wall models: Utilizing TEMPO-oxidized cellulose nanofibers for fucoxanthin delivery systems

Carbohydr Polym. 2025 Jan 15;348(Pt B):122850. doi: 10.1016/j.carbpol.2024.122850. Epub 2024 Oct 14.

Authors

Fang Tian¹, Shuyi Xu², Miaoyu Gan³, Baihui Chen⁴, Qian Luan⁵, Luyun Cai⁶

Affiliations

¹ Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China; Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo 315100, China. Electronic address: tianfang@zjou.edu.cn.
² Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China; Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo 315100, China. Electronic address: xushuyi@zjou.edu.cn.
³ Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo 315100, China.
⁴ Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China; Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo 315100, China.
⁵ Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo 315100, China; School of Chemical and Biological Engineering, NingboTech University, Ningbo 315100, China. Electronic address: luanqian@zju.edu.cn.
⁶ Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo 315100, China; School of Chemical and Biological Engineering, NingboTech University, Ningbo 315100, China. Electronic address: cailuyun@zju.edu.cn.

PMID: 39567111
DOI: 10.1016/j.carbpol.2024.122850

Abstract

Fucoxanthin (FX) has various excellent biological properties but suffers from poor bioavailability. In this work, we build a bionic cell wall model using TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-oxidized cellulose. The bionic cell wall enhances the environmental stability of the liposomes and serves as a pH-responsive mechanism. The coating processes protect the structure of liposomes and fucoxanthin under the acidic conditions of the stomach. The bionic cell wall disperses and releases the fucoxanthin in simulated intestinal fluid (SIF). Overall, the protective and release capabilities highlight the potential of cellulose in a bionic cell wall model and provide diversity for the structural design of carriers for delivering functional bioactive components.

Keywords: Fucoxanthin; Liposomes; Stability; TEMPO-oxidized cellulose nanofiber.

MeSH terms

Bionics
Cell Wall* / chemistry
Cellulose / chemistry
Cellulose, Oxidized / chemistry
Cyclic N-Oxides* / chemistry
Drug Carriers / chemistry
Drug Delivery Systems / methods
Drug Liberation
Hydrogen-Ion Concentration
Liposomes / chemistry
Nanofibers* / chemistry
Oxidation-Reduction
Xanthophylls* / administration & dosage
Xanthophylls* / chemistry
Xanthophylls* / pharmacology

Substances

Cyclic N-Oxides
TEMPO
fucoxanthin
Xanthophylls
Liposomes
Cellulose
Cellulose, Oxidized
Drug Carriers