Inhibition of Pyruvate Oxidation Diminishes Melanoma Progression

Berfin Seyran; Itzel Avila; Carlos Galvan; Genesis Robles; Conor Murphy; Heather R Christofk; William E Lowry

doi:10.1016/j.jid.2024.10.605

Inhibition of Pyruvate Oxidation Diminishes Melanoma Progression

J Invest Dermatol. 2024 Nov 19:S0022-202X(24)02902-6. doi: 10.1016/j.jid.2024.10.605. Online ahead of print.

Authors

Berfin Seyran¹, Itzel Avila², Carlos Galvan³, Genesis Robles⁴, Conor Murphy⁴, Heather R Christofk⁵, William E Lowry⁶

Affiliations

¹ Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA; Broad Center for Regenerative Medicine, University of California, Los Angeles, Los Angeles, California, USA.
² Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA; Broad Center for Regenerative Medicine, University of California, Los Angeles, Los Angeles, California, USA; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.
³ Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA; Broad Center for Regenerative Medicine, University of California, Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.
⁴ Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA.
⁵ Broad Center for Regenerative Medicine, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.
⁶ Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA; Broad Center for Regenerative Medicine, University of California, Los Angeles, Los Angeles, California, USA; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: blowry@ucla.edu.

PMID: 39566840
DOI: 10.1016/j.jid.2024.10.605

No abstract available

Keywords: Melanoma; Metabolism; Mitochondria; Mpc1; Stem cell.