Identification of the Novel HLA-DPA1*01:214 Allele in a Brazilian Bone Marrow Donor

HLA. 2024 Nov;104(5):e15774. doi: 10.1111/tan.15774.

Authors

Ana Paula Sokolowski de Lima¹, Rafael Formenton Cita², Fernanda Pelisson Massi^{1

3}, Bruna Karina Banin Hirata³, Jeane Eliete Laguila Visentainer³

Affiliations

¹ Postgraduate Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Brazil.
² Immunology Laboratory of Transplant - HLA, Cancer Hospital of Barretos, Barretos, Brazil.
³ Laboratory of Immunogenetics at the State University of Maringá (LIG-UEM). Department of Basic Health Sciences, State University of Maringá, Maringá, Brazil.

PMID: 39564903
DOI: 10.1111/tan.15774

Abstract

A single nucleotide polymorphism, changing Phenylalanine to Leucine, differentiates HLA-DPA1*01:214 from HLA-DPA1*01:03:01:01.

Keywords: HLA‐DPA1; nanopore; new allele; next‐generation sequencing; single nucleotide polymorphism.

© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MeSH terms

Alleles*
Amino Acid Substitution
Base Sequence
Bone Marrow Transplantation
Brazil
Codon
Exons*
HLA-DP alpha-Chains* / genetics
HLA-DP alpha-Chains* / immunology
Histocompatibility Testing
Humans
Polymorphism, Single Nucleotide*
Sequence Alignment
Sequence Analysis, DNA / methods
Tissue Donors*

Substances

HLA-DP alpha-Chains
HLA-DPA1 antigen
Codon