The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice

Maíra da Silva Almeida Rocha; Lucas Renan Sena de Oliveira; Diêgo Mendes Xavier; Natielle Cecília Dos Santos Ottone; Pedro Paulo Ribeiro Ferreira; Kaio Augusto Oliveira Paulino; Juliana Sales Rodrigues Costa; Graciene Fernandes Araújo Campos Fonseca; Gabriela Silva; Patrick Almeida Silva; Saulo Soares da Silva; João Paulo de Paula Almeida; Cândido Celso Coimbra; Elizabethe Adriana Esteves; Cleber Ferraresi; Flavio de Castro Magalhaes

doi:10.1111/php.14041

The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice

Photochem Photobiol. 2024 Nov 18. doi: 10.1111/php.14041. Online ahead of print.

Authors

Maíra da Silva Almeida Rocha¹, Lucas Renan Sena de Oliveira², Diêgo Mendes Xavier³, Natielle Cecília Dos Santos Ottone³, Pedro Paulo Ribeiro Ferreira⁴, Kaio Augusto Oliveira Paulino⁴, Juliana Sales Rodrigues Costa¹, Graciene Fernandes Araújo Campos Fonseca¹, Gabriela Silva^{1

2}, Patrick Almeida Silva³, Saulo Soares da Silva⁵, João Paulo de Paula Almeida⁵, Cândido Celso Coimbra^{1

6}, Elizabethe Adriana Esteves^{1

2

7}, Cleber Ferraresi⁸, Flavio de Castro Magalhaes^{1

2

4

9}

Affiliations

¹ Multicentric Graduate Program in Physiological Sciences, Federal University of the Jequitinhonha and Mucuri Valleys-UFVJM, Diamantina, Brazil.
² Graduate Program in Health Sciences, Federal University of the Jequitinhonha and Mucuri Valleys-UFVJM, Diamantina, Brazil.
³ Department of Physiotherapy, Federal University of the Jequitinhonha and Mucuri Valleys-UFVJM, Diamantina, Brazil.
⁴ Department of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys-UFVJM, Diamantina, Brazil.
⁵ Instituto de Ciências e Tecnologia, Federal University of the Jequitinhonha and Mucuri Valleys-UFVJM, Diamantina, Brazil.
⁶ Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
⁷ Department of Nutrition, Federal University of the Jequitinhonha and Mucuri Valleys-Diamantina, Diamantina, Brazil.
⁸ Department of Physical Therapy, Federal University of Sao Carlos-UFSCAR, Sao Carlos, Brazil.
⁹ Department of Health, Exercise, and Sports Sciences, University of New Mexico-UNM. Johnson Center, Albuquerque, New Mexico, USA.

PMID: 39555993
DOI: 10.1111/php.14041

Abstract

Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm²) composed of 20 LED clusters, 2.14 mW/cm²/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm²) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.

Keywords: light emitting diode therapy; low‐level laser therapy; photobiomodulation dosimetry; type 2 diabetes mellitus; whole‐body photobiomodulation.

Abstract

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