Increased antinuclear (anti-Sm) antibodies in infertile patients with peritoneal endometriosis

Renata Fogaça Borges; Vanessa Krebs Genro; Carlos Augusto Bastos de Souza; Tatiana Ferreira Michelon; Isabel Meneghetti Coimbra; João Sabino Lahorgue da Cunha-Filho

doi:10.5935/1518-0557.20240070

Increased antinuclear (anti-Sm) antibodies in infertile patients with peritoneal endometriosis

JBRA Assist Reprod. 2024 Nov 14. doi: 10.5935/1518-0557.20240070. Online ahead of print.

Authors

Renata Fogaça Borges¹, Vanessa Krebs Genro², Carlos Augusto Bastos de Souza², Tatiana Ferreira Michelon², Isabel Meneghetti Coimbra¹, João Sabino Lahorgue da Cunha-Filho³

Affiliations

¹ Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
² Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
³ Department of Obstetrics and Gynecology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

PMID: 39540605
DOI: 10.5935/1518-0557.20240070

Abstract

Objective: The aim of this study is to evaluate the intensity of five antibodies against extractable nuclear antigens (ENA: RNP, ScL-70, SS-B, SS-A, and Sm) in infertile patients with endometriosis.

Methods: We investigated infertile women with minimal/mild endometriosis (n=43) and fertile women (n=46).

Results: The intensity of immunoreactions was also similar for anti-RNP and anti-SS-A antibodies. However, the intensity of immunoreactivity for anti-Sm antibodies was higher in the endometriosis group.

Conclusions: Patients with minimal/mild endometriosis have higher levels of anti-Sm autoantibodies.

Keywords: anti-RNP autoantibodies; anti-SS-A antibodies.; anti-Sm autoantibodies; endometriosis; infertile.